BRCA mutation variants in ovarian cancer patients: Does the mutation class matter?
نویسندگان
چکیده
منابع مشابه
Breast cancer following ovarian cancer in BRCA mutation carriers.
IMPORTANCE BRCA mutation carriers are at increased risk of developing breast cancer. However, the incidence of breast cancer after a diagnosis of epithelial ovarian cancer (EOC), one of the tubal/peritoneal cancers collectively referred to as pelvic serous carcinomas, is not well known. Optimal breast cancer surveillance and detection for these patients have also not been well characterized. ...
متن کاملBRCA mutation in ovarian cancer: testing, implications and treatment considerations
Ovarian cancer is a heterogeneous disease that encompasses a number of different cellular subtypes, the most common of which is high-grade serous ovarian cancer (HGSOC). Still today, ovarian cancer is primarily treated with chemotherapy and surgery. Recent advances in the hereditary understanding of this disease have shown a significant role for the BRCA gene. While only a minority of patients ...
متن کاملMutation Screening of BRCA Genes in 10 Iranian Males with Breast Cancer
Male breast cancer is a rare disease with an increasing trend. Due to limited information especially about the genetic basis of the disease in Iran and the lower age of its onset, the disease requires more attention. The aim of this study was to screen the male patients with breast cancer for BRCA mutations as well as tissue markers of estrogen receptor (ER), progesterone receptor (PR), human e...
متن کاملRisk of metachronous breast cancer after BRCA mutation-associated ovarian cancer.
BACKGROUND This study sought to estimate the risk of breast cancer (BC) after a diagnosis of ovarian cancer (OC) associated with mutation of the BRCA1/2 (breast cancer, early onset) genes (BRCA-OC). METHODS The Memorial Sloan-Kettering Cancer Center and the University of Pennsylvania, clinical genetics databases were searched to identify women with BRCA-OC who participated in genetic testing ...
متن کاملThe 3020insC NOD2 gene mutation in patients with ovarian cancer.
OBJECTIVE There is an increasing evidence that genetic factors play a role in the etiology of malignant tumors. Mutations of BRCA1 and BRCA2 genes are responsible for an increased risk of ovarian cancer. The role of mutations in NOD2 gene in this type of neoplasm is still under investigation. THE AIM The aim of this study was to determine: 1. incidence of NOD 2 3020insC constitutional mutatio...
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ژورنال
عنوان ژورنال: Gynecologic Oncology
سال: 2016
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2016.04.359